22. Antibiotics, Analgesic Sedatives, and Antiseizure Medications Frequently Used in Critically Ill Neonates: A Narrative Review

Antibiotics, Analgesic Sedatives, and Antiseizure Medications Frequently Used in Critically Ill Neonates: A Narrative Review 

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CEUs: 2 Clinical

Average read time: 225 minutes.

Short Summary of the Article:

The document provides a comprehensive review of antibiotics, analgesic sedatives, and antiseizure medications used in critically ill neonates. It highlights the challenges of neonatal pharmacotherapy, particularly the variability in medication use across different neonatal intensive care units (NICUs). The article reviews the pharmacokinetics, safety profiles, recommended dosages, and evidence-based guidelines for antimicrobials, analgesics, and antiseizure medications. Special focus is given to the potential adverse effects of early antibiotic use on the neonatal microbiome and its long-term impacts on immune function, neurodevelopment, and other outcomes. The article also emphasizes the need for more rigorous clinical trials and better pharmacological strategies tailored to neonates.

Learning Outcomes 

Upon completion of this activity, you should have an understanding of:

1. Pharmacological Approaches in Neonates: Understanding the pharmacokinetics, safety, and recommended dosages of antibiotics, analgesics, and antiseizure medications used in critically ill neonates.
2. Impact of Early Antibiotic Use: Recognizing the potential long-term impacts of early antibiotic use on the neonatal microbiome and the risk of immune-related diseases and neurodevelopmental issues.
3. Evidence-Based Guidelines for Neonatal Care: Gaining insights into the latest evidence-based guidelines and clinical recommendations for managing neonatal pharmacotherapy in NICUs.

(Max of 3 Attempts)