31. Drug-resistant bacteria in the critically ill: patterns and mechanisms of resistance and potential remedies

Drug-resistant bacteria in the critically ill: patterns and mechanisms of resistance and potential remedies

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CEUs: 2 Clinical

Average read time: 40 minutes.

Short Summary of the Article:

This review article discusses the patterns and mechanisms of antimicrobial resistance in critically ill patients, particularly within the intensive care unit (ICU). It highlights the significant threat posed by multidrug-resistant (MDR) organisms, such as the ESKAPE pathogens, including Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species. The article outlines key factors contributing to antibiotic resistance, including overuse and improper use of antibiotics. The authors emphasize the need for effective antimicrobial stewardship, novel therapeutic strategies, and preventive measures like infection control and surveillance to address the growing challenge of antibiotic resistance.

Learning Outcomes 

Upon completion of this activity, you should have an understanding of:

1. The mechanisms by which multidrug-resistant organisms develop resistance, including genetic mutations and horizontal gene transfer.
2. The importance of antimicrobial stewardship programs in managing and preventing antibiotic resistance in the ICU setting.
3. Emerging therapeutic approaches and preventive strategies for controlling infections caused by multidrug-resistant bacteria in critically ill patients.

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