6. Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review
Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review
CEUs: 2 Clinical
Average read time: 155 minutes.
Short Summary of the Article:
This article discusses advancements in malaria pharmacology and outlines the significant steps toward the development of new treatments. It dives into several classes of anti-malarial agents and their mechanisms of action, exploring preclinical studies on novel inhibitors and their potential application in treating malaria. The article provides an extensive review of the current clinical trials and drug development efforts aimed at combating drug-resistant malaria strains.
Learning Outcomes
Upon completion of this activity, you should have an understanding of:
- Mechanisms of Malaria Drug Resistance: The biological and molecular pathways that lead to drug resistance in Plasmodium falciparum and other malaria-causing parasites.
- Current Advances in Anti-Malarial Drugs: The development of novel anti-malarial agents targeting both the blood and liver stages of malaria parasites.
- Pharmacokinetic and Pharmacodynamic Considerations: The challenges faced in the clinical development of new drugs, including their efficacy in field trials and laboratory settings.
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Earned Point(s): 0 of 0, (0) What is the primary target of novel anti-malarial agents discussed in this article? pg 21 Which mechanism is inhibited by compounds with a benzothiazole core scaffold? pg 22 True or False: Proteasome inhibitors are ineffective in combating malaria. pg 21 Which stage of the Plasmodium parasite life cycle is influenced by cGMP-dependent protein kinase? pg 22 What is a key feature of UCT943, the next-generation PI4K inhibitor? pg 22 True or False: Atovaquone resistance in Plasmodium parasites is linked to mutations in the parasite's cytochrome bc1. pg 21 Which of the following drugs targets malaria parasite histone deacetylases? pg 23 What is the significance of Plasmodium phosphatidylinositol-4-kinase inhibitors? pg 24 True or False: Malaria parasites resistant to atovaquone can still transmit via mosquitoes. pg 23 What mechanism is affected by cytochrome bc1 inhibitors in malaria parasites? pg 21 What is the potential impact of combining HDAC inhibitors with artemisinin? pg 24 Which of the following malaria life cycle stages is the focus of PI4K inhibitors? pg 23 What role does dihydroorotate dehydrogenase play in the malaria parasite? pg 21 Which strategy is used to prevent malaria transmission by mosquitoes? pg 22 What is the mechanism of action of proteasome inhibitors in malaria treatment? pg 21
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