7. Systematic review protocol to determine the most effective pharmacological and non-pharmacological interventions for the management of acute methamphetamine toxicity

Systematic review protocol to determine the most effective pharmacological and non-pharmacological interventions for the management of acute methamphetamine toxicity

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Average read time: 25 to 30 minutes

Short Summary of the Article:

The article titled “Systematic Review Protocol to Determine the Most Effective Pharmacological and Non-Pharmacological Interventions for the Management of Acute Methamphetamine Toxicity” outlines a systematic review protocol that seeks to assess both pharmacological and non-pharmacological strategies for managing acute methamphetamine intoxication. The study is focused on identifying interventions for methamphetamine-induced agitation and violence in emergency department settings. The primary objective is to review experimental studies that assess the effectiveness of these interventions in reducing agitation, violence, and psychosis, with a focus on the time to achieve sedation and de-escalation. Secondary outcomes include evaluating the length of stay in the emergency department, mortality, and provider satisfaction.

Learning Outcomes 

Upon completion of this activity, you should have an understanding of:

1. Pharmacological and Non-Pharmacological Interventions for Methamphetamine Intoxication: The effectiveness of interventions such as benzodiazepines, antipsychotics, and verbal de-escalation in managing violent behavior in methamphetamine-intoxicated patients.
2. Clinical Application in Emergency Departments: Insights into how these interventions impact clinical outcomes, including de-escalation times, patient safety, and emergency department stays.
3. Importance of Standardized Protocols: Recognition of the variability in approaches to methamphetamine intoxication and the need for standardized evidence-based protocols to improve patient and staff safety.